Mikael, an Armenian medical student, moves to Constantinople, where he meets Ana and journalist Chris Myers. A love triangle forms as political tensions rise.
When the Armenian Genocide begins, Mikael is imprisoned but escapes to find his family suffering. He marries a childhood friend to protect them.
Chris tries to expose the genocide, while Ana helps orphaned children. Mikael and Ana reunite, struggling to survive amid the chaos.
They flee with refugees to Mount Musa Dagh, where French forces rescue them. Mikael survives but loses Ana, dedicating his life to helping Armenian orphans.